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Genotype-Guided Hydralazine Therapy.
Collins KS, Raviele ALJ, Elchynski AL, Woodcock AM, Zhao Y, Cooper-DeHoff RM, Eadon MT. Collins KS, et al. Am J Nephrol. 2020;51(10):764-776. doi: 10.1159/000510433. Epub 2020 Sep 14. Am J Nephrol. 2020. PMID: 32927458 Free PMC article. Review.
BACKGROUND: Despite its approval in 1953, hydralazine hydrochloride continues to be used in the management of resistant hypertension, a condition frequently managed by nephrologists and other clinicians. Hydralazine hydrochloride undergoes metabolism by the N-acetyltran …
BACKGROUND: Despite its approval in 1953, hydralazine hydrochloride continues to be used in the management of resistant hypertension, a cond …
Acetylation.
Weber WW. Weber WW. Birth Defects Orig Artic Ser. 1990;26(1):43-65. Birth Defects Orig Artic Ser. 1990. PMID: 2224079 Review.
Differences in individual acetylating capacity are ascribed to differences in the activities of the arylamine acetylating enzymes (isozymic N-acetyltransferase variants) of the liver, intestinal mucosa and certain other tissues. ...All suitable test ag …
Differences in individual acetylating capacity are ascribed to differences in the activities of the arylamine acetylating enzymes (is …
Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles: a mini review.
Hein DW, Fakis G, Boukouvala S. Hein DW, et al. Pharmacogenet Genomics. 2018 Oct;28(10):238-244. doi: 10.1097/FPC.0000000000000350. Pharmacogenet Genomics. 2018. PMID: 30222709 Free PMC article. Review.
The arylamine N-acetyltransferase (NAT) nomenclature committee assigns functional phenotypes for human arylamine N-acetyltransferase 1 (NAT1) alleles in those instances in which the committee determined a consensus has been achieved in the scientific l …
The arylamine N-acetyltransferase (NAT) nomenclature committee assigns functional phenotypes for human arylamine N-a …
Familial bladder cancer and the related genes.
Hemminki K, Bermejo JL, Ji J, Kumar R. Hemminki K, et al. Curr Opin Urol. 2011 Sep;21(5):386-92. doi: 10.1097/MOU.0b013e32834958ff. Curr Opin Urol. 2011. PMID: 21738036 Review.
Family members also share prognosis of bladder cancer, either good or poor survival. Among the low-penetrant genes, the variants within the genes encoding metabolic enzymes have been consistently associated with susceptibility to bladder cancer and the evidence is c …
Family members also share prognosis of bladder cancer, either good or poor survival. Among the low-penetrant genes, the variants with …
Polymorphic NATs and cancer predisposition.
Hirvonen A. Hirvonen A. IARC Sci Publ. 1999;(148):251-70. IARC Sci Publ. 1999. PMID: 10493262 Review.
Therefore, it has been suggested that slow acetylator status may modify the individual responses to various chemicals. ...While three of the NAT2 variants have been shown to account for most of the slow NAT2 acetylator genotypes in Caucasians, l …
Therefore, it has been suggested that slow acetylator status may modify the individual responses to various chemicals. ...Whil …
Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.
Hengstler JG, Arand M, Herrero ME, Oesch F. Hengstler JG, et al. Recent Results Cancer Res. 1998;154:47-85. doi: 10.1007/978-3-642-46870-4_4. Recent Results Cancer Res. 1998. PMID: 10026993 Review.
This review gives an overview on relevant polymorphisms of four families of drug-metabolizing enzymes. Rapid acetylators (with respect to N-acetyltransferase NAT2) were shown to have an increased risk of colon cancer, but a decreased risk of bladder ca …
This review gives an overview on relevant polymorphisms of four families of drug-metabolizing enzymes. Rapid acetylators (with …
Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes.
Thier R, Brüning T, Roos PH, Rihs HP, Golka K, Ko Y, Bolt HM. Thier R, et al. Int J Hyg Environ Health. 2003 Jun;206(3):149-71. doi: 10.1078/1438-4639-00209. Int J Hyg Environ Health. 2003. PMID: 12872524 Review.
Several genotypes of this isozyme have been characterised which seem to be associated with different levels of expression of enzyme activity. The acetylator status for NAT2 can be determined by genotyping or by phenotyping. ...Interestingly, the underlying European …
Several genotypes of this isozyme have been characterised which seem to be associated with different levels of expression of enzyme a …